Thursday 29 September 2016

Nyaderm Vaginal Cream



Generic Name: nystatin (Vaginal route)

nye-STAT-in

Commonly used brand name(s)

In Canada


  • Mycostatin

  • Mycostatin Vaginal Cream

  • Nadostine

  • Nilstat Vaginal Cream

  • Nilstat Vaginal Tablet

  • Nyaderm Vaginal Cream

Available Dosage Forms:


  • Cream

  • Tablet

Therapeutic Class: Antifungal


Chemical Class: Polyene


Uses For Nyaderm Vaginal Cream


Nystatin belongs to the group of medicines called antifungals. Vaginal nystatin is used to treat fungus infections of the vagina. Nystatin vaginal cream or tablets may also be used for other problems as determined by your doctor.


Nystatin is available only with your doctor's prescription.


Before Using Nyaderm Vaginal Cream


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Studies on this medicine have been done only in adults, and there is no specific information comparing use of vaginal nystatin in children with use in other age groups.


Geriatric


Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing the use of vaginal nystatin in the elderly with use in other age groups.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.


Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Proper Use of nystatin

This section provides information on the proper use of a number of products that contain nystatin. It may not be specific to Nyaderm Vaginal Cream. Please read with care.


Nystatin usually comes with patient directions. Read them carefully before using this medicine.


This medicine is usually inserted into the vagina with an applicator. However, if you are pregnant, check with your doctor before using the applicator to insert the vaginal tablet.


To help clear up your infection completely, keep using this medicine for the full time of treatment, even if your condition has improved. Also, keep using this medicine even if you begin to menstruate during the time of treatment. Do not miss any doses.


Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For treating fungus (yeast) infections:
    • For vaginal cream dosage form:
      • Adults and teenagers—One 100,000-unit applicatorful inserted into the vagina one or two times a day for two weeks. Or, your doctor may want you to insert one 500,000-unit applicatorful into the vagina once a day.

      • Children—Dose must be determined by your doctor.


    • For vaginal tablet dosage form:
      • Adults and teenagers—One 100,000-unit tablet inserted into the vagina one or two times a day for two weeks.

      • Children—Dose must be determined by your doctor.



Missed Dose


If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Storage


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Precautions While Using Nyaderm Vaginal Cream


To help cure the infection and to help prevent reinfection, good health habits are required.


  • Wear cotton panties (or panties or pantyhose with cotton crotches) instead of synthetic (for example, nylon, rayon) underclothes.

  • Wear freshly laundered underclothes.

If you have any questions about this, check with your health care professional.


If you have any questions about douching or intercourse during the time of treatment with nystatin, check with your doctor.


Since there may be some vaginal drainage while you are using this medicine, a sanitary napkin may be worn to protect your clothing.


Nyaderm Vaginal Cream Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor as soon as possible if any of the following side effects occur:


Rare
  • Vaginal burning or itching not present before use of this medicine

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More Nyaderm Vaginal Cream resources


  • Nyaderm Vaginal Cream Use in Pregnancy & Breastfeeding
  • Nyaderm Vaginal Cream Support Group
  • 6 Reviews for Nyaderm Vaginal - Add your own review/rating


Compare Nyaderm Vaginal Cream with other medications


  • Cutaneous Candidiasis
  • Vaginal Yeast Infection

Periostat


Generic Name: doxycycline (DOX i SYE kleen)

Brand Names: Adoxa, Adoxa CK, Adoxa TT, Alodox, Avidoxy, Doryx, Monodox, Oracea, Oraxyl, Periostat, Vibramycin, Vibramycin Calcium, Vibramycin Monohydrate


What is Periostat (doxycycline)?

Doxycycline is a tetracycline antibiotic. It fights bacteria in the body.


Doxycycline is used to treat many different bacterial infections, such as urinary tract infections, acne, gonorrhea, and chlamydia, periodontitis (gum disease), and others.


Doxycycline is also used to treat blemishes, bumps, and acne-like lesions caused by rosacea. Doxycycline will not treat facial redness caused by rosacea.


Doxycycline may also be used for purposes not listed in this medication guide.


What is the most important information I should know about Periostat (doxycycline)?


Do not use this medicine if you are pregnant. It could harm the unborn baby or cause permanent tooth discoloration later in life.

Doxycycline can make birth control pills less effective. Ask your doctor about using a non hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using doxycycline.


You should not take this medicine if you are allergic to doxycycline or to other tetracycline antibiotics such as demeclocycline (Declomycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

Before taking doxycycline, tell your doctor if you have liver disease, kidney disease, asthma, or if you are allergic to sulfites.


Drink plenty of liquids while you are taking doxycycline. Children should not use doxycycline. Doxycycline can cause permanent yellowing or graying of the teeth in children younger than 8 years old. Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.

What should I discuss with my healthcare provider before taking Periostat (doxycycline)?


You should not take this medicine if you are allergic to doxycycline or to other tetracycline antibiotics such as demeclocycline (Declomycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

To make sure you can safely take doxycycline, tell your doctor if you have any of these other conditions:



  • liver disease;




  • kidney disease; or




  • asthma or sulfite allergy.



If you are using doxycycline to treat gonorrhea, your doctor may test you to make sure you do not also have syphilis, another sexually transmitted disease.


FDA pregnancy category D. Do not use doxycycline if you are pregnant. It could harm the unborn baby or cause permanent tooth discoloration later in life. Tell your doctor right away if you become pregnant during treatment.

Doxycycline can make birth control pills less effective. Ask your doctor about using a non hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using doxycycline.


Doxycycline passes into breast milk and may affect bone and tooth development in a nursing baby. You should not breast-feed while you are taking doxycycline. Children should not use doxycycline. Doxycycline can cause permanent yellowing or graying of the teeth in children younger than 8 years old.

How should I take Periostat (doxycycline)?


Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.


Take doxycycline with a full glass of water. Drink plenty of liquids while you are taking doxycycline.

Different brands of doxycycline may have different instructions about taking them with or without food.


Most brands of doxycyline may be taken with food or milk if the medicine upsets your stomach. Take Oracea or Periostat on an empty stomach, at least 1 hour before or 2 hours after a meal.

You may open a Doryx capsule or break up a Doryx tablet and sprinkle the medicine into a spoonful of applesauce to make swallowing easier. Swallow right away without chewing. Do not save the mixture for later use. Drink a full glass (8 ounces) of cool water right away.


Do not crush, break, or open a delayed-release capsule. Swallow the pill whole. Breaking or opening the pill may cause too much of the drug to be released at one time. The enteric coated pill has a special coating to protect your stomach. Breaking the pill will damage this coating.

Measure liquid medicine with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one.


Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Doxycycline will not treat a viral infection such as the common cold or flu.

If you need surgery, tell the surgeon ahead of time that you are using doxycycline. You may need to stop using the medicine for a short time.


Store at room temperature away from moisture and heat. Throw away any unused medicine after the expiration date on the label has passed. Using expired doxycycline can cause damage to your kidneys.

What happens if I miss a dose?


Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, and diarrhea.


What should I avoid while taking Periostat (doxycycline)?


Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking doxycycline and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.


Avoid exposure to sunlight or tanning beds. Doxycycline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Do not take iron supplements, multivitamins, calcium supplements, antacids, or laxatives within 2 hours before or after taking doxycycline.

Periostat (doxycycline) side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

  • severe headache, dizziness, blurred vision;




  • fever, chills, body aches, flu symptoms, swollen glands, rash or itching, joint pain, or general ill feeling;




  • urinating less than usual or not at all;




  • diarrhea that is watery or bloody




  • pale or yellowed skin, dark colored urine, fever, confusion or weakness;




  • severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;




  • loss of appetite, jaundice (yellowing of the skin or eyes); or




  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.



Less serious side effects may include:



  • mild nausea, mild diarrhea;




  • upset stomach;




  • mild skin rash or itching; or




  • vaginal itching or discharge.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect Periostat (doxycycline)?


Tell your doctor about all other medicines you use, especially:



  • cholesterol-lowering medications such as cholestyramine (Prevalite, Questran) or colestipol (Colestid);




  • isotretinoin (Accutane);




  • tretinoin (Renova, Retin-A, Vesanoid);




  • an antacid such as Tums, Rolaids, Milk of Magnesia, Maalox, and others;




  • a product that contains bismuth subsalicylate such as Pepto-Bismol;




  • minerals such as iron, zinc, calcium, magnesium, and over-the-counter vitamin and mineral supplements;




  • a blood thinner such as warfarin (Coumadin, Jantoven); or




  • a penicillin antibiotic such as amoxicillin (Amoxil, Augmentin, Dispermox, Moxatag), ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen).



This list is not complete and other drugs may interact with doxycycline. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.



More Periostat resources


  • Periostat Side Effects (in more detail)
  • Periostat Use in Pregnancy & Breastfeeding
  • Drug Images
  • Periostat Drug Interactions
  • Periostat Support Group
  • 0 Reviews for Periostat - Add your own review/rating


  • Periostat MedFacts Consumer Leaflet (Wolters Kluwer)

  • Periostat Prescribing Information (FDA)

  • Periostat Advanced Consumer (Micromedex) - Includes Dosage Information

  • Doxycycline Prescribing Information (FDA)

  • Doxycycline Professional Patient Advice (Wolters Kluwer)

  • Doxycycline Monograph (AHFS DI)

  • Doxycycline MedFacts Consumer Leaflet (Wolters Kluwer)

  • Adoxa MedFacts Consumer Leaflet (Wolters Kluwer)

  • Alodox Prescribing Information (FDA)

  • Doryx Prescribing Information (FDA)

  • Doryx Delayed-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)

  • Doxycycline Calcium Monograph (AHFS DI)

  • Monodox Prescribing Information (FDA)

  • Ocudox Convenience Kit MedFacts Consumer Leaflet (Wolters Kluwer)

  • Oracea Consumer Overview

  • Oracea Prescribing Information (FDA)

  • Vibra-Tabs MedFacts Consumer Leaflet (Wolters Kluwer)

  • Vibramycin Prescribing Information (FDA)



Compare Periostat with other medications


  • Periodontitis


Where can I get more information?


  • Your pharmacist can provide more information about doxycycline.

See also: Periostat side effects (in more detail)


Nutraderm


Generic Name: topical emollients (TOP i kal ee MOL i ents)

Brand Names: Aloe Vesta Cream, AlphaSoft, AmeriPhor, Aqua Glycolic, Aqua Lube, Aquaphor, Aveeno, Baby Lotion, Baby Oil, Bag Balm, Baza-Pro, Beta Care, Blistex Lip Balm, Carmex, CarraKlenz, CeraVe, CeraVe AM, Cetaphil Lotion, Chap Stick, Citraderm, CoolBottoms, Corn Huskers Lotion, Curel Moisture Lotion, Derma Soothe, Dr Scholl's Essentials Cracked Skin Repair, Eucerin, Herpecin-L, K-Y Jelly, Keri Lotion, Lamisilk Heel Balm, Lubri-Soft, Lubriderm, Mederma, Moisturel, Natural Ice, NeutrapHor, NeutrapHorus Rex, Neutrogena Cleansing, Neutrogena Lotion, Nivea, Nutraderm, Pacquin, Phisoderm, Pretty Feet & Hands, Proshield Skincare Kit, Remedy 4-in-1 Cleansing Lotion, Replens, Secura, Sensi-Care, Soft Sense, St. Ives, Theraplex Lotion, Vaseline Intensive Care


What are Nutraderm (topical emollients)?

Emollients are substances that moisten and soften your skin.


Topical (for the skin) emollients are used to treat or prevent dry skin. Topical emollients are sometimes contained in products that also treat acne, chapped lips, diaper rash, cold sores, or other minor skin irritation.


There are many brands and forms of topical emollients available and not all are listed on this leaflet.


Topical emollients may also be used for purposes not listed in this medication guide.


What is the most important information I should know about Nutraderm (topical emollients)?


You should not use a topical emollient if you are allergic to it. Topical emollients will not treat or prevent a skin infection.

Ask a doctor or pharmacist before using this medication if you have deep wounds or open sores, swelling, warmth, redness, oozing, bleeding, large areas of skin irritation, or any type of allergy.


What should I discuss with my healthcare provider before using Nutraderm (topical emollients)?


You should not use a topical emollient if you are allergic to it. Topical emollients will not treat or prevent a skin infection.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have:



  • deep wounds or open sores;




  • swelling, warmth, redness, oozing, or bleeding;




  • large areas of skin irritation;




  • any type of allergy; or



  • if you are pregnant or breast-feeding.

How should I use Nutraderm (topical emollients)?


Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.


Clean the skin where you will apply the topical emollient. It may help to apply this product when your skin is wet or damp. Follow directions on the product label.


Shake the product container if recommended on the label.

Apply a small amount of topical emollient to the affected area and rub in gently.


If you are using a stick, pad, or soap form of topical emollient, follow directions for use on the product label.


Do not use this product over large area of skin. Do not apply a topical emollient to a deep puncture wound or severe burn without medical advice.

If your skin appears white or gray and feels soggy, you may be applying too much topical emollient or using it too often.


Some forms of topical emollient may be flammable and should not be used near high heat or open flame, or applied while you are smoking.

Store as directed away from moisture, heat, and light. Keep the bottle, tube, or other container tightly closed when not in use.


What happens if I miss a dose?


Since this product is used as needed, it does not have a daily dosing schedule. Seek medical advice if your condition does not improve after using a topical emollient.


What happens if I overdose?


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Nutraderm (topical emollients)?


Avoid getting topical emollients in your eyes, nose, or mouth. If this does happen, rinse with water. Avoid exposure to sunlight or tanning beds. Some topical emollients can make your skin more sensitive to sunlight or UV rays.

Nutraderm (topical emollients) side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using the topical emollient and call your doctor if you have severe burning, stinging, redness, or irritation where the product was applied.

Less serious side effects are more likely, and you may have none at all.


This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect Nutraderm (topical emollients)?


It is not likely that other drugs you take orally or inject will have an effect on topically applied products. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.



More Nutraderm resources


  • Nutraderm Use in Pregnancy & Breastfeeding
  • Nutraderm Support Group
  • 0 Reviews for Nutraderm - Add your own review/rating


  • Biafine Emulsion MedFacts Consumer Leaflet (Wolters Kluwer)

  • Campath Monograph (AHFS DI)

  • Campral Monograph (AHFS DI)

  • Camptosar Monograph (AHFS DI)

  • Diabinese Monograph (AHFS DI)

  • Kinerase Cream MedFacts Consumer Leaflet (Wolters Kluwer)

  • Neosalus Foam MedFacts Consumer Leaflet (Wolters Kluwer)

  • Promiseb Cream MedFacts Consumer Leaflet (Wolters Kluwer)



Compare Nutraderm with other medications


  • Dry Skin


Where can I get more information?


  • Your pharmacist can provide more information about topical emollients.


Wednesday 28 September 2016

Norvasc



Generic Name: amlodipine (Oral route)

am-LOE-di-peen

Commonly used brand name(s)

In the U.S.


  • Norvasc

Available Dosage Forms:


  • Tablet

  • Tablet, Disintegrating

Therapeutic Class: Cardiovascular Agent


Pharmacologic Class: Calcium Channel Blocker


Chemical Class: Dihydropyridine


Uses For Norvasc


Amlodipine is used alone or together with other medicines to treat angina (chest pain) and high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.


Amlodipine is a calcium channel blocker. It affects the movement of calcium into the cells of the heart and blood vessels. As a result, amlodipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.


This medicine is available only with your doctor's prescription.


Before Using Norvasc


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Appropriate studies have not been performed on the relationship of age to the effects of amlodipine to treat high blood pressure in children younger than 6 years of age. Safety and efficacy have not been established.


Geriatric


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of amlodipine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving amlodipine.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Amiodarone

  • Atazanavir

  • Conivaptan

  • Dantrolene

  • Droperidol

  • Simvastatin

  • Telaprevir

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Acebutolol

  • Alprenolol

  • Atenolol

  • Betaxolol

  • Bevantolol

  • Bisoprolol

  • Bucindolol

  • Carteolol

  • Carvedilol

  • Celiprolol

  • Clopidogrel

  • Dalfopristin

  • Dilevalol

  • Diltiazem

  • Esmolol

  • Fluconazole

  • Imatinib

  • Indinavir

  • Itraconazole

  • Ketoconazole

  • Labetalol

  • Levobunolol

  • Mepindolol

  • Metipranolol

  • Metoprolol

  • Nadolol

  • Nebivolol

  • Oxprenolol

  • Penbutolol

  • Pindolol

  • Propranolol

  • Quinupristin

  • Rifapentine

  • Ritonavir

  • Sotalol

  • St John's Wort

  • Talinolol

  • Tertatolol

  • Timolol

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Angina (chest pain) or

  • Heart attack, acute or

  • Heart or blood vessel disease (e.g., coronary artery disease) or

  • Hypotension (low blood pressure)—Use with caution. May make these conditions worse.

  • Heart disease or other heart problems (e.g., aortic stenosis)—Use with caution. The blood pressure-lowering effects of this medicine may be increased.

  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of Norvasc


Take this medicine exactly as directed even if you feel well and do not notice any chest pain. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Do not miss any doses.


For patients taking this medicine for high blood pressure:


  • In addition to the use of the medicine, treatment for your high blood pressure may include weight control and a change in the types of food you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

  • Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

  • Remember that this medicine will not cure your high blood pressure but it does help control it. Therefore, you must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life . If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

You may take this medicine with or without food.


Take this medicine at the same time each day.


Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For oral dosage form (tablets):
    • For angina (chest pain):
      • Adults—5 to 10 milligrams (mg) once a day.

      • Children—Use and dose must be determined by your doctor.


    • For high blood pressure:
      • Adults—At first, 2.5 to 5 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 10 mg once a day.

      • Children 6 to 17 years of age—2.5 to 5 mg once a day.

      • Children younger than 6 years of age—Use and dose must be determined by your doctor.



Missed Dose


If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Do not take this medicine if it has been more than 12 hours since you missed your last dose.


Storage


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Ask your healthcare professional how you should dispose of any medicine you do not use.


Precautions While Using Norvasc


It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects. a


Dizziness, lightheadedness, or fainting may also occur if you exercise or if the weather is hot. Heavy sweating can cause loss of too much water and result in low blood pressure. Use extra care during exercise or hot weather.


If you have been using this medicine regularly for several weeks, do not suddenly stop using it. Stopping suddenly may cause your chest pain or high blood pressure to come back or get worse. Check with your doctor for the best way to reduce gradually the amount you are taking before stopping completely.


Chest pain resulting from exercise or physical exertion is usually reduced or prevented by this medicine. This may tempt you to be too active. Make sure you discuss with your doctor a safe amount of exercise for your medical problem.


After taking a dose of this medicine you may get a headache that lasts for a short time. This should become less noticeable after you have taken this medicine for a while. If this effect continues, or if the headaches are severe, check with your doctor.


In some patients, tenderness, swelling, or bleeding of the gums may appear soon after treatment with this medicine is started. Brushing and flossing your teeth carefully and regularly and massaging your gums may help prevent this. See your dentist regularly to have your teeth cleaned. Check with your doctor or dentist if you have any questions about how to take care of your teeth and gums, or if you notice any tenderness, swelling, or bleeding of your gums.


Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may increase your blood pressure.


Norvasc Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


More common
  • Swelling of the ankles or feet

Less common
  • Difficult or labored breathing

  • dizziness

  • fast, irregular, pounding, or racing heartbeat or pulse

  • feeling of warmth

  • redness of the face, neck, arms, and occasionally, upper chest

  • shortness of breath

  • tightness in the chest

  • wheezing

Rare
  • Black, tarry stools

  • bleeding gums

  • blistering, peeling, or loosening of the skin

  • blood in the urine or stools

  • blurred vision

  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

  • chest pain or discomfort

  • chills

  • cold and clammy skin

  • cold sweats

  • confusion

  • dark yellow urine

  • cough

  • diarrhea

  • dilated neck veins

  • dizziness or lightheadedness when getting up from a lying or sitting position

  • extra heartbeats

  • extreme fatigue

  • fainting

  • fever

  • itching of the skin

  • joint or muscle pain

  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

  • numbness and tingling of the face, fingers, or toes

  • pain in the arms, legs, or lower back, especially pain in the calves or heels upon exertion

  • painful or difficult urination

  • pale, bluish-colored, or cold hands or feet

  • pinpoint red or purple spots on the skin

  • red, irritated eyes

  • redness of the face, neck, arms, and occasionally, upper chest

  • redness, soreness or itching skin

  • shakiness in the legs, arms, hands, or feet

  • slow or irregular heartbeat

  • sore throat

  • sores, ulcers, or white spots on the lips or in the mouth

  • sores, welting, or blisters

  • sudden sweating

  • sweating

  • swelling of the face, fingers, feet, or lower legs

  • swollen glands

  • trembling or shaking of the hands or feet

  • unsteadiness or awkwardness

  • unusual bleeding or bruising

  • unusual tiredness or weakness

  • weak or absent pulses in the legs

  • weakness in the arms, hands, legs, or feet

  • weight gain

  • yellow eyes or skin

Incidence not known
  • Abdominal or stomach pain

  • clay-colored stools

  • diarrhea

  • headache

  • loss of appetite

  • nausea

  • rash

  • unpleasant breath odor

  • vomiting of blood

  • yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


Less common
  • Acid or sour stomach

  • belching

  • heartburn

  • indigestion

  • lack or loss of strength

  • muscle cramps

  • sleepiness or unusual drowsiness

  • stomach discomfort, upset, or pain

Rare
  • Abnormal dreams

  • anxiety

  • back pain

  • bad unusual or unpleasant (after) taste

  • bleeding gums

  • blistering, crusting, irritation, itching, or reddening of the skin

  • bloating

  • bloody nose

  • burning feeling in the chest or stomach

  • burning while urinating

  • burning, dry, or itching eyes

  • change in color of the treated skin

  • change in sense of smell

  • change in taste

  • changes in vision

  • constipation

  • continuing ringing or buzzing or other unexplained noise in the ears

  • cracked, dry, or scaly skin

  • decreased sexual performance or desire

  • depression

  • difficulty with moving

  • difficulty with swallowing

  • discharge, excessive tearing

  • double vision

  • dry mouth

  • dryness of the skin

  • excess air or gas in the stomach or intestines

  • excessive muscle tone

  • eye pain

  • feeling of constant movement of self or surroundings

  • feeling of unreality

  • feeling unusually cold

  • flushed, dry skin

  • fruit-like breath odor

  • full feeling

  • general feeling of discomfort or illness

  • hair loss or thinning of the hair

  • headache, severe and throbbing

  • hearing loss

  • hyperventilation

  • increased appetite

  • increased hunger

  • increased sweating

  • increased thirst

  • increased urge to urinate during the night

  • increased urination

  • irritability

  • irritation in the mouth

  • lack of feeling or emotion

  • loose stools

  • loss of memory

  • muscle pains or stiffness

  • muscle tension or tightness

  • muscle weakness

  • nervousness

  • pain

  • pains in the stomach, side, or abdomen, possibly radiating to the back

  • passing gas

  • problems with memory

  • redness and swelling of the gums

  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

  • restlessness

  • runny nose

  • seeing double

  • sensation of spinning

  • sense of detachment from self or body

  • shakiness and unsteady walk

  • shivering

  • sleeplessness

  • sneezing

  • stuffy nose

  • sweating

  • swollen joints

  • tenderness in the stomach area

  • thirst

  • trouble in holding or releasing urine

  • trouble sleeping

  • twitching

  • unable to sleep

  • uncaring

  • unexplained weight loss

  • unsteadiness, trembling, or other problems with muscle control or coordination

  • waking to urinate at night

  • weight loss

Incidence not known
  • Swelling of the breasts or breast soreness in both females and males

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Norvasc side effects (in more detail)



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More Norvasc resources


  • Norvasc Side Effects (in more detail)
  • Norvasc Use in Pregnancy & Breastfeeding
  • Drug Images
  • Norvasc Drug Interactions
  • Norvasc Support Group
  • 28 Reviews for Norvasc - Add your own review/rating


  • Norvasc Prescribing Information (FDA)

  • Norvasc Consumer Overview

  • Norvasc MedFacts Consumer Leaflet (Wolters Kluwer)

  • Amlodipine Prescribing Information (FDA)

  • Amlodipine Professional Patient Advice (Wolters Kluwer)

  • Amlodipine Besylate Monograph (AHFS DI)



Compare Norvasc with other medications


  • Angina
  • Coronary Artery Disease
  • Heart Failure
  • High Blood Pressure
  • Migraine Prevention
  • Raynaud's Syndrome

Nabilone


Class: Antiemetics, Miscellaneous
VA Class: GA605
Chemical Name: (±) - trans - 3 - (1,1 - dimethylheptyl) - 6,6a,7,8,10,10a - hexahydro - 1 - hydroxy - 6 - 6 - dimethyl - 9H - dibenzo[b,d]pyran - 9 - one
Molecular Formula: C24H36O3
CAS Number: 51022-71-0
Brands: Cesamet

Introduction

Antiemetic; a synthetic cannabinoid.1 2 6 15


Uses for Nabilone


Cancer Chemotherapy-induced Nausea and Vomiting


Prevention of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic therapy.1 2 3 4 5 8 10 11 15


ASCO does not consider cannabinoids (e.g., nabilone, dronabinol) appropriate first-line antiemetics for any group of patients receiving chemotherapy of high emetic risk and states that these drugs should be reserved for patients unable to tolerate or refractory to first-line agents (i.e., a type 3 serotonin [5-HT3] receptor antagonist [e.g., dolasetron, granisetron, ondansetron, palonosetron] with dexamethasone and aprepitant).11 14


Nabilone Dosage and Administration


Administration


Oral Administration


Administer orally without regard to meals.1 2 5 Has been administered IV; however, a parenteral preparation is not commercially available in the US.1 2 6


Dosage


Adults


Cancer Chemotherapy-induced Nausea and Vomiting

Oral

Usual dose: 1 or 2 mg twice daily; administer initial dose 1–3 hours before chemotherapy.1 2 May be administered 2 or 3 times daily during the entire chemotherapy cycle and for 48 hours after the last dose of chemotherapy in each cycle.1 2


Initiate with the lower dosage (i.e., 1 mg twice daily) to minimize adverse effects, then increase dosage as necessary up to a maximum of 2 mg 3 times daily.1 2


May administer a dose of 1 or 2 mg the night prior to chemotherapy.1 2


Prescribing Limits


Adults


Cancer Chemotherapy-induced Nausea and Vomiting

Oral

Maximum: 2 mg 3 times daily.1 2


Special Populations


Hepatic Impairment


No specific dosage recommendations at this time.1


Renal Impairment


No specific dosage recommendations at this time.1


Geriatric Patients


Select dosage with caution, usually initiating at the lower end of the recommended dosage range because of possible age-related decreases in hepatic, renal, and/or cardiac function; concomitant diseases and drug therapy; and possible increased sensitivity to adverse effects.1 (See Geriatric Use under Cautions.)


Cautions for Nabilone


Contraindications


Hypersensitivity to any cannabinoid.1 2


Warnings/Precautions


Warnings


Effects of nabilone may persist for a variable and unpredictable period of time following oral administration.1 2 3 5 12


CNS Effects

CNS effects, including dizziness, drowsiness or sedation, euphoria (i.e., “high”), ataxia, anxiety, disorientation, depression, hallucinations, and psychosis, reported.1 2 4 5 6 7 8 12 Adverse psychiatric reactions can persist for 48–72 hours following discontinuance of nabilone.1 2 5 12


Individual response and tolerance may vary; a responsible adult should supervise patients, particularly during initial therapy and during dosage adjustments.1 2


Cardiovascular Effects

May cause tachycardia and orthostatic hypotension.1 2 3 4 5 6 8 12 Elevations in supine and standing heart rates also reported.1 2 3 4 5 6 8 12


Individual response and tolerance may vary; a responsible adult should supervise patients, particularly during initial therapy and during dosage adjustments.1 2 Carefully evaluate the potential risks and benefits of the drug; use with caution in geriatric patients and in patients with hypertension and/or cardiovascular disease.1 2 4 12 (See Geriatric Use under Cautions.)


General Precautions


Psychiatric Disorders

Use with caution in patients with current or history of psychiatric disorders (e.g., bipolar disorder, depression, schizophrenia); cannabinoid use may unmask the symptoms of these diseases.1 2


Abuse Potential

Marijuana contains an active compound similar to nabilone.1 2 Use nabilone with caution in patients with history of substance abuse, including alcohol abuse or dependence and marijuana use.1 2 Increased risk of substance abuse in patients with personal or family history of substance abuse or mental illness.1 2 Monitor patients receiving nabilone for signs of excessive use, abuse, and misuse.1 8 12


High potential for abuse.1 2 Limit prescriptions to quantity necessary for a single cycle of chemotherapy (i.e., a few days);1 2 not intended for use on an as-needed basis or as the initial prescribed antiemetic therapy.1 2 15


Specific Populations


Pregnancy

Category C.1 2


Lactation

Not known whether nabilone is distributed into milk.1 2 Avoid use in nursing women.1 2


Pediatric Use

Safety and effectiveness not established.1 2 Caution is advised because of psychoactive effects.1 2


Geriatric Use

Insufficient experience in patients ≥65 years of age to determine whether they respond differently than younger adults.1 2 Use with caution because of increased sensitivity to psychoactive effects and risk of elevated supine and standing heart rates and postural hypotension.1 2 12


Hepatic Impairment

Not studied in patients with hepatic impairment.1 2


Renal Impairment

Not studied in patients with renal impairment.1 2


Common Adverse Effects


Adverse effects may be similar to those of marijuana (cannabis) and other cannabinoids.1 2 12 13


Drowsiness, vertigo, dry mouth, ataxia, euphoria (i.e., feeling “high”), dysphoria, sleep disturbances, headache.1 2 4 5 6 7 8 12 13


Interactions for Nabilone


Nabilone is a synthetic cannabinoid; interactions reported with Cannabis sativa L (marijuana) also may occur with nabilone.1 2


Extensively metabolized by multiple CYP isoenzymes.1 2


Does not substantially inhibit CYP isoenzymes 1A2, 2A6, 2C19, 2D6, and 3A4; weak inhibitor of 2E1 and 3A4 isoenzymes and a moderate inhibitor of 2C8 and 2C9 isoenzymes.1 2


Drugs Metabolized by Hepatic Microsomal Enzymes


Inhibitors or inducers of CYP isoenzymes: possible altered nabilone metabolism.1 2


Pharmacokinetic interaction with drugs metabolized by CYP isoenzymes unlikely because very low plasma nabilone concentrations are achieved with clinical use.1 2


Protein-bound Drugs


Possible displacement of other protein-bound drugs.1 2 Monitor patients and adjust dosages as necessary.1 2


Specific Drugs







































Drug



Interaction



Comments



Alcohol



Possible additive drowsiness and CNS depression; increase in the positive subjective mood effects reported with smoked marijuana 1 2



Avoid alcohol during therapy1 2



Anticholinergic agents (e.g., antihistamines, atropine, scopolamine)



Possible additive or super-additive anticholinergic effects (e.g., tachycardia, drowsiness) 1 2



Antidepressants, tricyclic (e.g., amitriptyline, amoxapine, desipramine)



Possible additive tachycardia, hypertension, or drowsiness1 2



Antipyrine



Possible decreased antipyrine clearance1 2



CNS depressants (e.g., antihistamines, barbiturates, benzodiazepines, buspirone, hypnotics, lithium, muscle relaxants, sedatives)



Possible additive drowsiness and CNS depression1 2


Possible decreased barbiturate clearance1 2



Administer with caution1 2



Disulfiram



Reversible hypomanic reaction reported in a disulfiram-treated patient who smoked marijuana1 2



Fluoxetine



Hypomanic reaction reported in a fluoxetine-treated patient after smoking marijuana; symptoms resolved within 4 days1 2



Naltrexone



Possible enhanced effects of oral delta-9-tetrahydrocannabinol observed during opiate receptor blockade1 2



Opiate agonists (e.g., meperidine, methadone, propoxyphene, tramadol)



Possible additive drowsiness and CNS depression; possible cross-tolerance and potentiation of other pharmacologic effects1 2



Sympathomimetic agents (e.g., amphetamines, cocaine)



Possible additive hypertension, tachycardia, or cardiotoxicity1 2



Theophylline



Increased theophylline metabolism reported with marijuana smoking; similar to that reported following tobacco smoking 1 2


Nabilone Pharmacokinetics


Absorption


Bioavailability


Appears to be completely absorbed from the GI tract after oral administration, with peak plasma concentrations achieved within 2 hours.1


Food


Food does not appear to significantly affect the rate or extent of absorption.1


Distribution


Extent


Volume of distribution: Approximately 12.5 L/kg.1


Elimination


Metabolism


Extensively metabolized, including metabolism via multiple CYP isoenzymes, to several metabolites; relative pharmacologic activities of the metabolites and the parent drug not established.1 2


Elimination Route


Following IV administration, nabilone and its metabolites are eliminated principally in feces (approximately 67%) and to a lesser extent in urine (approximately 22%) within 7 days.1 2


Following oral administration, about 60% of nabilone and its metabolites were recovered in feces and about 24% in urine.1 2 The principal excretory pathway appears to be the biliary system.1 2


No substantial accumulation of nabilone observed after chronic oral administration, but metabolites may accumulate at concentrations in excess of the parent drug with repeated administration.1 2


Half-life


Approximately 2 hours.1


Plasma half-life of total radioactivity (identified and unidentified metabolites) is approximately 35 hours.1


Stability


Storage


Oral


Capsules

25°C (may be exposed to 15–30°C).1


ActionsActions



  • Exerts complex effects on CNS.1 2 6 12 15




  • Antiemetic effect may be caused by interaction with the cannabinoid receptor system, including the cannabinoid 1 (CB1) receptors in the central and peripheral nervous system.1 2 12 15




  • Binds to cannabinoid 2 (CB2) receptors in the spleen and other peripheral tissues, which may play a role in the immunosuppressive effects of cannabinoids.2 12 15




  • Like other cannabinoids, may possess analgesic, antispasmodic, and muscle relaxant activity; however, further evaluation is necessary.2 10 15



Advice to Patients



  • Risk of additive or synergistic CNS depression during concurrent use with alcohol or other CNS depressants, including benzodiazepines and barbiturates.1 2 Importance of avoiding alcohol and other CNS depressants during nabilone therapy.1 2




  • Importance of avoiding driving, operating machinery, or performing hazardous tasks during nabilone therapy.1 2




  • Importance of informing patients about possible changes in mood and other adverse behavioral effects of nabilone to avoid panic if such manifestations occur.1




  • Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as concomitant illnesses.1




  • Importance of informing patients that they should remain under the supervision of a responsible adult during therapy.1 2




  • Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.1




  • Importance of informing patients of other important precautionary information.1 2 (See Cautions.)



Preparations


Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.


Subject to control under the Federal Controlled Substances Act of 1970 as a schedule II (C-II) drug.1 2













Nabilone

Routes



Dosage Forms



Strengths



Brand Names



Manufacturer



Oral



Capsules



1 mg



Cesamet ( C-II; with povidone)



Valeant



Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.


The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions September 2007. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.




References



1. Valeant Pharmaceuticals International. Cesamet (nabilone) capsules prescribing information. Costa Mesa, CA; 2006 Jul.



2. Valeant Pharmaceuticals North America. Cesamet (nabilone) capsules, 1 mg: innovations in omnineuromodulation formulary dossier. Costa Mesa, CA; 2006 Jun 21.



3. Tramer MR, Carroll D, Campbell FA et al. Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review. Br Med J. 2001; 323:1-8.



4. Einhorn LH, Nagy C, Furnas B et al. Nabilone: an effective antiemetic in patients receiving cancer chemotherapy. J Clin Pharmacol. 1981; 21:64-9S.



5. Herman TS, Einhorn LH, Jones SE et al. Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy. N Engl J Med. 1979; 300:1295-7. [PubMed 375088]



6. Lemberger L, Rowe H. Clinical pharmacology of nabilone, a cannabinol derivative. Clin Pharmacol Ther. 1975; 18:720-6. [PubMed 1204278]



7. Talbott JA, Teague JW. Marijuana psychosis: acute toxic psychosis associated with the use of Cannabis derivatives. JAMA. 1969; 210:299-302. [PubMed 5394365]



8. Ahmedzai S, Carlyle DL, Calder IT et al. Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy. Br J Cancer. 1983; 48:657-63. [PubMed 6315040]



9. Williamson EM, Evans FJ. Cannabinoids in clinical practice. Drugs. 2000; 60:1303-14. [PubMed 11152013]



10. Croxford JL. Therapeutic potential of cannabinoids in CNS disease. CNS Drugs. 2003; 17:179-202. [PubMed 12617697]



11. Kris MG, Hesketh PJ, Somerfield MR et al. American Society of Clinical Oncology guideline for antiemetics in oncology: update 2006. J Clin Oncol. 2006; 24:1-16. [PubMed 16330665]



12. Ashton CH. Adverse effects of cannabis and cannabinoids. Br J Anaesthesia. 1999; 83:637-49.



13. Herman TS, Jones SE, Dean J et al. Nabilone: a potent antiemetic cannabinol with minimal euphoria. Biomedicine. 1977; 27:331-4. [PubMed 606307]



14. Gralla RJ, Osoba D, Kris MG et al. Recommendations for the use of antiemetics: evidence-based, clinical practice guidelines. J Clin Oncol. 1999; 17:2971-94. [PubMed 10561376]



15. Ben Amar M. Cannabinoids in medicine: a review of their therapeutic potential. J Ethnopharmacol. 2006; 105:1-25. [PubMed 16540272]



More Nabilone resources


  • Nabilone Side Effects (in more detail)
  • Nabilone Dosage
  • Nabilone Use in Pregnancy & Breastfeeding
  • Nabilone Drug Interactions
  • Nabilone Support Group
  • 1 Review for Nabilone - Add your own review/rating


  • Nabilone MedFacts Consumer Leaflet (Wolters Kluwer)

  • Nabilone Professional Patient Advice (Wolters Kluwer)

  • nabilone Advanced Consumer (Micromedex) - Includes Dosage Information

  • Cesamet Prescribing Information (FDA)

  • Cesamet Consumer Overview



Compare Nabilone with other medications


  • Fibromyalgia
  • Nausea/Vomiting, Chemotherapy Induced

Tuesday 27 September 2016

Nafrinse


Generic Name: fluoride (FLOR ide)

Brand Names: Altaflor, Ethedent Chewable, Fluor-A-Day, Fluoritab, Flura-Drops, Flura-Loz, Flura-Tab, Karidium, Lozi-Flur, Luride, Nafrinse, Pharmaflur, Pharmaflur 1.1


What is Nafrinse (fluoride)?

Fluoride is a substance that strengthens tooth enamel. This helps to prevent dental cavities.


Fluoride is used as a medication to prevent tooth decay in people that have a low level of fluoride in their drinking water. Fluoride is also used to prevent tooth decay in people who undergo radiation of the head and/or neck, which may cause dryness of the mouth and an increased incidence of tooth decay.


Fluoride may also be used for other purposes not listed in this medication guide.


What is the most important information I should know about Nafrinse (fluoride)?


You should not use fluoride if the level of fluoride in your drinking water is greater than 0.7 parts per million (ppm).

Before using fluoride, tell your dentist and doctor if you are on a low salt or a salt free diet. You may not be able to use fluoride, or you may need special tests while you are using it.


Do not take fluoride with milk, other dairy products, or calcium supplements. Calcium can make it harder for your body to absorb fluoride.

Avoid using antacids without your doctor's advice. Use only the specific type of antacid your doctor recommends. Many antacids contain calcium, which can interfere with fluoride absorption.


What should I discuss with my healthcare provider before taking Nafrinse (fluoride)?


You should not use fluoride if the level of fluoride in your drinking water is greater than 0.7 parts per million (ppm).

Before using fluoride, tell your dentist and doctor if you are on a low salt or a salt free diet. You may not be able to use fluoride, or you may need special tests while you are using it.


Talk to your doctor and dentist before taking fluoride if you are pregnant or could become pregnant during treatment. Talk to your doctor and dentist before taking fluoride if you are breast-feeding. The American Dental Association's Council on Dental Therapeutics recommends the use of fluoride by children up to 13 years of age; the American Academy of Pediatrics recommends fluoride supplementation by children until the age of 16 years of age. Do not give a 1-mg tablet to a child younger than 3 years old, or when your drinking water fluoride content is equal to or greater than 0.3 ppm.

How should I take Nafrinse (fluoride)?


Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.


Take this medicine with a full glass of water. Do not take fluoride with milk or other dairy products. Calcium can make it harder for your body to absorb fluoride.

Suck on the fluoride lozenge until it dissolves completely in your mouth. Do not chew the lozenge or swallow it whole.


The chewable forms of fluoride can be chewed, swallowed, dissolved in the mouth, added to drinking water or fruit juice, or added to water for use in infant formula or other food.


The fluoride drops can be taken by mouth undiluted, or mixed with fluid or food.


If you mix fluoride with food or water, drink or eat this mixture right away. Do not save it for later use.


It is important to take fluoride regularly to get the most benefit.


Store fluoride at room temperature away from moisture and heat.

What happens if I miss a dose?


Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting, stomach pain, diarrhea, drooling, numbness or tingling, loss of feeling anywhere in your body, muscle stiffness, or seizure (convulsions).


What should I avoid while taking Nafrinse (fluoride)?


Do not take fluoride with milk, other dairy products, or calcium supplements. Calcium can make it harder for your body to absorb fluoride.

Avoid using antacids without your doctor's advice. Use only the specific type of antacid your doctor recommends. Many antacids contain calcium, which can interfere with fluoride absorption.


Nafrinse (fluoride) side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor if you have any of the following side effects:

  • discolored teeth;




  • weakened tooth enamel; or




  • any changes in the appearance of your teeth.



Less serious side effects may include:



  • stomach upset;




  • headache; or




  • weakness.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect Nafrinse (fluoride)?


There may be other drugs that can interact with fluoride. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.



More Nafrinse resources


  • Nafrinse Use in Pregnancy & Breastfeeding
  • Nafrinse Support Group
  • 0 Reviews for Nafrinse - Add your own review/rating


  • Epiflur Prescribing Information (FDA)

  • Fluor-A-Day Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

  • Fluor-A-Day Advanced Consumer (Micromedex) - Includes Dosage Information

  • Fluor-a-Day Prescribing Information (FDA)

  • Fluorides Monograph (AHFS DI)

  • Fluoritab Drops MedFacts Consumer Leaflet (Wolters Kluwer)

  • Lozi-Flur Lozenges MedFacts Consumer Leaflet (Wolters Kluwer)



Compare Nafrinse with other medications


  • Prevention of Dental Caries


Where can I get more information?


  • Your pharmacist can provide more information about fluoride.


Nuquin HP


Generic Name: hydroquinone topical (HYE droe KWIN one)

Brand Names: Aclaro, Aclaro PD, Alera, Alphaquin HP, Alustra, Claripel, Eldopaque, Eldopaque Forte, Eldoquin, Eldoquin Forte, EpiQuin Micro, Esoterica, Esoterica with Sunscreen, Glyquin, Glyquin-XM, Hydroquinone and Sunscreen, Lustra, Lustra-AF, Lustra-Ultra, Melpaque HP, Melquin HP, Melquin-3, Nuquin HP, Solaquin, Solaquin Forte


What is Nuquin HP (hydroquinone topical)?

Hydroquinone decreases the formation of melanin in the skin. Melanin is the pigment in skin that gives it a brown color.


Hydroquinone topical is used to lighten areas of darkened skin such as freckles, age spots, chloasma, and melasma.


Hydroquinone topical may also be used for other purposes not listed in this medication guide.


What is the most important information I should know about Nuquin HP (hydroquinone topical)?


Before using hydroquinone topical, tell your doctor if you are allergic to any drugs, or if you have liver or kidney disease.


Do not use hydroquinone topical on skin that is sunburned, windburned, dry, chapped, or irritated, or on an open wound. It could make these conditions worse. Wait until these conditions have healed before applying hydroquinone topical. Avoid getting this medication in your mouth or eyes. If it does get into any of these areas, rinse with water.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.


Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Hydroquinone topical can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

What should I discuss with my healthcare provider before using Nuquin HP (hydroquinone topical)?


Do not use hydroquinone topical on skin that is sunburned, windburned, dry, chapped, or irritated, or on an open wound. It could make these conditions worse. Wait until these conditions have healed before applying hydroquinone topical.

Before using hydroquinone topical, tell your doctor if you are allergic to any drugs, or if you have:



  • liver disease; or




  • kidney disease.



If you have any of these conditions, you may need a dose adjustment or special tests to safely use this medication.


This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether hydroquinone topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use Nuquin HP (hydroquinone topical)?


Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.


Hydroquinone topical is for external use only. Wash your hands before and after applying this medication, unless you are treating a skin area on your hand.

Apply the medication to clean, dry skin. Apply just enough medication to cover the affected area. Avoid applying to the unaffected surrounding skin. Rub in the medication gently and completely.


Avoid getting this medication on your lips or inside your nose or mouth. Hydroquinone may cause numbness of these areas. If the medication does get on any of these areas, rinse with water.


It is important to use hydroquinone topical regularly to get the most benefit.


Store hydroquinone topical at room temperature away from moisture and heat.

What happens if I miss a dose?


Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of topically applied hydroquinone is not likely to cause life-threatening symptoms.


What should I avoid while using Nuquin HP (hydroquinone topical)?


Avoid getting this medication in your mouth or eyes. If it does get into any of these areas, rinse with water. Do not use hydroquinone topical on sunburned, windburned, dry, chapped, irritated, or broken skin.

Your skin may be more sensitive to weather extremes such as cold and wind. Protect your skin with clothing and use a moisturizing cream or lotion as needed.


Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.


Using hydroquinone topical together with benzoyl peroxide, hydrogen peroxide, or other peroxide products may cause a temporary staining of your skin. This staining can usually be removed with soap and water. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Hydroquinone topical can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

Nuquin HP (hydroquinone topical) side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using hydroquinone topical and call your doctor if you have severe burning, stinging, or other irritation of your skin after apply the medication.

Less serious side effects may include mild burning, stinging, itching, redness, or irritation of treated skin.


This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect Nuquin HP (hydroquinone topical)?


It is not likely that other drugs you take orally or inject will have an effect on topically applied hydroquinone. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.



More Nuquin HP resources


  • Nuquin HP Side Effects (in more detail)
  • Nuquin HP Use in Pregnancy & Breastfeeding
  • Nuquin HP Support Group
  • 0 Reviews for Nuquin HP - Add your own review/rating


  • Alustra MedFacts Consumer Leaflet (Wolters Kluwer)

  • Epiquin Micro Prescribing Information (FDA)

  • Esoterica Cream MedFacts Consumer Leaflet (Wolters Kluwer)

  • Solaquin Forte Cream MedFacts Consumer Leaflet (Wolters Kluwer)



Compare Nuquin HP with other medications


  • Dermatological Disorders


Where can I get more information?


  • Your pharmacist can provide more information about hydroquinone topical.

See also: Nuquin HP side effects (in more detail)


Nalfon


Generic Name: fenoprofen (fen oh PROE fen)

Brand Names: Nalfon


What is Nalfon (fenoprofen)?

Fenoprofen is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Fenoprofen works by reducing hormones that cause inflammation and pain in the body.


Fenoprofen is used to treat pain or inflammation caused by arthritis.


Fenoprofen may also be used for other purposes not listed in this medication guide.


What is the most important information I should know about Nalfon (fenoprofen)?


This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).


Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.


This medicine can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking fenoprofen. Older adults may have an even greater risk of these serious gastrointestinal side effects.


Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.


What should I discuss with my healthcare provider before taking Nalfon (fenoprofen)?


Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).


NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.


Do not use this medication if you are allergic to fenoprofen, or if you have:

  • severe kidney disease;




  • a stomach ulcer or inflammatory bowel disease; or




  • a history of allergic reaction to aspirin or other NSAIDs.



If you have any of these other conditions, you may need a dose adjustment or special tests to safely take fenoprofen:



  • a history of heart attack, stroke, or blood clot;




  • heart disease, congestive heart failure, high blood pressure;




  • a history of stomach ulcers or bleeding, bowel problems, diverticulosis;



  • liver or kidney disease;


  • asthma;




  • polyps in your nose; or




  • if you smoke.




FDA pregnancy category C. It is not known whether fenoprofen is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking fenoprofen during the last 3 months of pregnancy may result in birth defects. Do not take fenoprofen during pregnancy unless your doctor has told you to. Fenoprofen can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medicine to a child younger than 14 years old without the advice of a doctor.

How should I take Nalfon (fenoprofen)?


Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. The maximum amount of fenoprofen for adults is 3 grams (3000 mg) per day. Know the amount of fenoprofen in the specific product you are taking.


If you take fenoprofen for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor.


This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using fenoprofen.


Store fenoprofen at room temperature, away from moisture, heat, and light.

What happens if I miss a dose?


Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting, confusion, dizziness, drowsiness, black or bloody stools, coughing up blood, fever, urinating less than usual or not at all, shallow breathing, fainting, or coma.


What should I avoid while taking Nalfon (fenoprofen)?


Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain medicines similar to fenoprofen (such as aspirin, ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen. Do not drink alcohol while taking fenoprofen. Alcohol can increase the risk of stomach bleeding. Fenoprofen can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Nalfon (fenoprofen) side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking fenoprofen and seek medical attention or call your doctor at once if you have any of these serious side effects:

  • chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;




  • black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;




  • confusion, tremors or shaking;




  • urinating less than usual or not at all;




  • pain, burning, or bleeding when you urinate;




  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);




  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or




  • bruising, severe tingling, numbness, pain, muscle weakness.



Less serious side effects may include:



  • upset stomach, mild heartburn or stomach pain, diarrhea, constipation; bloating, gas;




  • dizziness, headache, nervousness;




  • skin itching or rash;




  • dry mouth;




  • increased sweating, runny nose;




  • blurred vision; or




  • ringing in your ears.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect Nalfon (fenoprofen)?


Tell your doctor if you are taking an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor). Taking any of these drugs with fenoprofen may cause you to bruise or bleed easily.


Before taking fenoprofen, tell your doctor if you are taking:



  • cyclosporine (Gengraf, Neoral, Sandimmune);




  • lithium (Eskalith, Lithobid);




  • diuretics (water pills) such as furosemide (Lasix);




  • aspirin or salicylates such as Doan's Pills, Dolobid, and others;




  • a blood thinner such as warfarin (Coumadin);




  • steroids (prednisone and others);




  • seizure medication such as phenobarbital (Luminal, Solfoton) or phenytoin (Dilantin);




  • a sulfa drug such as Bactrim or Septra;




  • oral diabetes medications such as glipizide (Glucotrol), glimepiride (Amaryl, Duetact, Avandaryl), and others; or




  • aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), nabumetone (Relafen), naproxen (Aleve, Naprosyn), meloxicam (Mobic), piroxicam (Feldene), and others.



This list is not complete and there may be other drugs that can interact with fenoprofen. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.



More Nalfon resources


  • Nalfon Side Effects (in more detail)
  • Nalfon Use in Pregnancy & Breastfeeding
  • Drug Images
  • Nalfon Drug Interactions
  • Nalfon Support Group
  • 1 Review for Nalfon - Add your own review/rating


  • Nalfon Prescribing Information (FDA)

  • Nalfon Monograph (AHFS DI)

  • Nalfon Advanced Consumer (Micromedex) - Includes Dosage Information

  • Nalfon MedFacts Consumer Leaflet (Wolters Kluwer)

  • Fenoprofen Prescribing Information (FDA)

  • Fenoprofen MedFacts Consumer Leaflet (Wolters Kluwer)



Compare Nalfon with other medications


  • Gout, Acute
  • Osteoarthritis
  • Pain
  • Rheumatoid Arthritis


Where can I get more information?


  • Your pharmacist can provide more information about fenoprofen.

See also: Nalfon side effects (in more detail)